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Metode RPTLC dan Optimal Fase dalam Penetapan Harga sebagai Salah Satu Parameter Lipofilisitas dalam Rancangan Obat

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RPTLC and optimizing moble phase methoda in Rm value determination as one of lipophylicity parameters in drug design. The early process to succesfully achieve its target is drug penetration. Of the thre physicochemical parameters i.e, lipophyllicity, electronic and stric parameters, the lipopmeters, the lipophylicity parameter is the most reponsible in drug absorption process. The research was aimed to determine relention modified(Rm) value of barbituric acid compound derivatives using RPTLC metod and mobile phase optimizing. This study was conducted on barbituric acid compound derivatives using RPTLC metod and mobile phase optimizing. This study was conducted on barbituric acid compound derivatives by using reverse phase thin layer chromatography (RPTLC). Silica Gel GF 254 that had been submerget in the mixture of liquid paraffin and petroleum ater (95:5) was used in a satistionary phase. The mixture of polar to non polar solvent was used as mobile phase. Research showed that in this method the most optimum of mobile phase was indicated by methanol and acetic acid mixture in the ratio of (1:9). The resulted Rm values of 5.5-diethylbarbituric acid. 5,5-diallybarbiture acid, 5-allyl-5-isopropylbarbituric acid, 5-allyl-5-isobuthylbarbituric acid were as follow 0.116; 0.162;0.221; 0.262;0187 and 0.199 conclusion : The most optimum mobile phase in this method was the mixwd solvents that had lower polarity, i.e,the mix of methanol and acetic in the ratio of. The H1, H2 and H3 substituens in barbituric acid nuclei showed, the longer carbon chain, the higher the Rm values, howover the existing of double bond in such substituens will decrease the Rm value.

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Media Medika Indonesiana:43(5):254-259

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Semarang : FK Diponegoro dan Ikatan Dokter Indonesia Jateng., 2009

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0126-1762

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ABSORPTION
PEUNECTRAUCE
CHROMATOLOGYTHIN LOYER
PHRAMACEUTICALPREPARATIONS

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