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Pengaruh Polifenol Teh Hijau terhadap Eistem Imun Penderita Karsinoma Nasofaring yang Mendapat Radioterapi Kajian Jumlah Monosit, Limfosit serta Produksi TNF-alpa, IFN-lamda dan IL-2 ex vivo

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The efffect of green tea polyphenols on the immunity of nasopharyngeal carcinoma patients treated with radiotherapy αstudy on the number of monocytes and lyphocytes, and production of TNF-α, IFN-ϒ and IL-2 ex vivo. Radiotherapy in patient with nasopharyngeal carcinoma gives side effects, among other is the suppression of immunity system. Green tea polyphenols (GTP) has proven to modulate immune system. The study aimed in analyze the capacity of antioxident GTP in inhibiting the suppression effect of radiotherapy to the immune system using monocytes, lymphocytes, TNF-α, IFN-ϒ and IL-2 parameter. An experiment study using pre-post test entrol group design was conducted to 50 NPC patients in IL, III and IV stages, received 200 cGy/day 33 times. The treatment group was 25 patients cansumed GTP (2900 mg of decaffeinated extract of green tea, containing 986 mg EGCG and 1711 mg of other polyhenols) 2 hours and 10 hours after RT. Th 10 ml blood of cubiti vein was taken 5 to 7 days prior and 3-5 hours after the whole RT. Monocytes and lymphocytes were cultured with autologous whole blood and TNF-α secretion of monocytes having been induced with LPS, IFN-ϒ and IL-2 by lymphocytes having been induced with PHA and LPS respectively , were measured using ELISa .In the post RT, the control, monocyte, TNF-α, IFN-ϒ and IL-2 had decreased, and the treatment group, monocyte, lymphocyte, and TNF-α decrease, while IFN-ϒ and IL-2 increase. The t-test transformation logarithan data of monocyte, lymphocyte, and TNF-α comparing the two groups, the result of monocyte and lymphocyte was significantly different (p

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Call Number

Media Medika Indonesiana:43(4):174-181

Publisher

Semarang : FK Diponegoro dan Ikatan Dokter Indonesia Jateng., 2009

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ISBN/ISSN

0126-1762

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Subject(s)

adenocarcinoma
INTERLEUKIN-2
TUMORNECROSIS FOCTER-ALPA
NOSOPHARYNGX

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