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The role of Triptans in the Management of Migraine

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Migraine is one of the most prevalent disorders seen in clinical practice today and also a major cause of disability in the workplase. The prevalence of migraine is highest during the years of peak productivity, ie. Between the ages of 25 and 55years. The triptams are a group of selective 5-hydroxtriptamine (HT), serotonin receptor agonists that activate the 5-HT receptor and possibly also the 5-HT.dan 5-HT receptor. To date 7 subslasses of serotonin receptors have been idetified, namely subclasses 5-HT to 5-HT. Triptan causes cranial vasoconstriction, inhibits peripheral trigeminal activity and the trigeminal afferents. With its triple action, triptans can control acute attacks of migraine. Triptan is contrain dicated in patients with previous ischenic or conronary artery disease., cerebral or peripheral vascular disease and other cardiovascular disorders. Triptams should be given immediately after an acute attack of migrain. The tripans are useful in the management of an acute migraine, but are not indicated for preventive therapy of migrain. Several new advances in migraine management have been made in regard to the recognitin of the pathogeneis of migraine, and the phenomenon of central sensitization. More treatment options become available to patients and prescribers, the impact of such therapy on worker productivity will become more important in determining the value of such intervention.

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Detail Information

Series Title

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Call Number

Universa:28(1):49-58

Publisher

Grogol Jakarta : Trisakti University., 2009

Collation

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Language

English

ISBN/ISSN

1907-3062

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

MIGRAINE DISORDERS
RECEPTORS, SEROTONIN

Specific Detail Info

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