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Potensi AMPK dan CaMK II sebagai Alternatif Jalur Ambilan Glukosa Otot pada Pencegahan dan Penatalaksanaan Diabetes Tipe 2( The Potention of AMPK and CaMK II as Alternative Muscle Glucose Uptake Pathway on Management and Prevention of Type 2 Diabetes)

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Untill nowadays, management and prevention in type 2 diabetes mellitus are still rely on pharmacological modality which optimilization the function of insulin to triger the muscle glucose uptake. Insulin and OAD can cause insulin dependency and fastened the irreversible diabetic phase. AMPK and CaMKII are protein kinases existing in skeletal muscle cytoplasm, which activated the uptake of muscle glucose without the influence of insulin. The expression and activity of AMPK and CMKII are elevated in the actively contracted muscle, such as in exercise. The use of transduction signal without the influen of insulin can avoid the destruction of beta cell. AMPK and CaMKII are very potential in management and prevention type 2 diabetes mellitus, viewed from the insulin resistence progressivity and the pancreatic beta cell destruction.

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Majalah Ilmu Faal Indonesia:9(1):58-61

Publisher

Surabaya : Ikatan Ahli Ilmu Faal Indonesia., 2009

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ISBN/ISSN

0215-1995

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Subject(s)

respiratory muscles
BLOOD GLUCOSE
DIABETES MELLITUS TYPE 2

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