Text

Optimasi Chittosan, Natrium Karboksi Metil Selulose dan Magnesium Stearat sebagai Sistem Mucoadhesive Tablet Karptopril (Optimization of Chitosan, Sodium Carboxy Methyl CeCelulose and Magnesium Stearat as Mucoadhesive System in Captropil Tablet)

---

Captropril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and some types of congestive heart failure. It has been reported that the duration of antihypertensive action after a single oral dose of captropril in only 6-8 h. Captropil is most stable at acidic condition and as the pH increases, it becomes unstable and undergoes a degradation reaction. These indicates a promising potential of the captropil mucoadhesive system as an alternative to the conventional dosage form. The objective of the current study was to find an optimun formula of mucoadhesive tablet for captropil using factorial design. Tablets were evaluated for mucoadhesive strength and drug release profile. The studies were performed to establish composition of chitosan, sodium CMC and Mg stearat. Such composiAtion could produce mucoadhesive strength with a zero order release kinetics. A 2³ factorial design has been applied to systematically optimize the formula. The amounts of chitosan (xB), and Mg stearat (Xc) were selected as independent variables, Mucoadhesive strength and dissolution effficiency (DE480) were selected as dependent variables. According the contour plot suggested that optimum formula will be reach mucoadhesive strength (26-30 g) and DE480 (≥70%) chitosan at low to middie level (20-35 mg), sodium CMC at middle to high level (150-200 mg), and Mg stearat at low middle level (4-6 mg).

---

Availability

Detail Information

Series Title

-

Call Number

Majalah Farmasi Indonesia:20(4):231-238

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2009

Collation

-

Language

ISBN/ISSN

0126-1037

Classification

-

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

sodium
SHITOSAN
CARBOXYMETHYLCELLULOSE
CAPTORIL

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment