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Efek Ekstrak Metanolik dan Fraksi Metanolik Sisa Buah Mengkudu terhadap Peningkatan Jumlah Protein GLIT-4 (The Effect of Menkudu Fruit Methanolic Extract and Methanolic Residual Fraction on GLUT-4 Protein Elevation)

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Investigating in the Diabetes Mellitus drug which one having good activity and tolerance to patients are still in researchers concern. One of the main topics now days is the use of mengkudu plants as a traditional medicine of Diabetes Mellitus. This research was aimed to determine the increase of GLUT-4 protein in type 2 Diabetes Mellitus rats after given methanolic extract and methanolic resudual of mengkudu fruit. The male rats were diabetic induced exogenous i.p. insulin for 10 days. After showing hyperglycemic effect, the rats were giwen orally methanolic extract and methanolic residual fraction of mengkudu fruit for 4 days. On the fifth day, fasting blood glucose was measured and the rats were sacrificed to take the thigh muscle tissue for immunohistochemical calculation. The result showed that methanolic extract and methanoic resudial of mengkudu fruit increase the amount of GLUT-4 protein, but can not reduce fasting blood glucose levels male white rats.

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Series Title

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Call Number

Majalah Farmasi Indonesia:20(4):170177

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2009

Collation

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Language

ISBN/ISSN

0126-1037

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Edition

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Subject(s)

DIABETES MELITIS TYPE 2
PLANTS - MEDICINAL

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