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Pengaruh Campuran Asam Oleat-Propilen Glikol dan Iontoforesia terhadap Transpor Transdermal Propranolol (The Influence of Oleic Cid-Propylene Glycol Mixture and Iotophoresis to Propranolol Transdermal Transport)

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Propranolol has an intensive first pass metabolism. Resulted in a low oral biovailability. One alternative first pass metabolism, resulted in a low oral biovailability. One alternative to circumvent such problem is the delivery by transdermal route. The objective of this study was to evaluate the effect of oleic and 10% (in propylene glycol 20%) as enhancer, with and without lotophoresis, on transdermal transport of propranolol. Propranolol delivery was examined based on the in vitro transport studies across the rat skin (after hair removal) in a vertical diffusion cells system. Skin was pretreated with the mixture of oleic acid 10% (in propylene glycol 20%) for 3 hours. Iontophoresis was performed at a current density of 0.25 mA/cm2 for 3 hours. Donor compartment was filled with propranolol solution (5 mg/mL in citric buffer pH 5), while the acceptor phase was filled with phosphate saline at pH 7.4.. The results indicate that the enhancement methods increase the transdermal penetration of propranolol (p

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia:20(4):217-223

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2009

Collation

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Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

PROPRANOLOL
IONTOPHORESIS
OLEIC ACID

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