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Assay Method Validation of Triamcinolone Acetanids (TA) to support the Investigation of TA-Ioaded Nenoparticies

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The aim or this study was to develop the valid analytical method which used for the assay of triamcinolone acetonids (TA) in the investigation of TA-loaded nenoparticle formulations: High Parformance Liquid Chromatography (HPLC) method was aplied in this study by using an Econosil calumn, C18 10um, 250 x 4.6 mm (Alltech Asociates Inc, PA, USA) as the stationary phase. The mobile phase consisted of a compostion of acetonitrile (ACN) and 20 mM phosphate buffer solution (pH 4.2) in the proportion of 20:50 v/v. The HPLC assay of TA was valldated for selectivity, linearity, precsion, recovery (accuracy), sensitivity and stability of TA during the assay. Results whowed that the concentration of TA in the samples can be determined against the standard in the concentration range of celibration curve. The system praction and level of recovery were consisdered to be acceptable, and the method was selective and sensitive.

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia:20(4):178-184

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2009

Collation

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Language

English

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

TRIACINOLONE ACETONIDE

Specific Detail Info

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