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Sintesis Kuersetin Terklorinasi Terklorinasi dan Aktivitas Perlindung terhadap Tukak Lambung (Synthesis and Gastric Ulcer Protective Activity of Chlorinated Quercetin)

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Gastrointestinal toxicity due to non-steroid anti-inflamatory drugs can be inhibited by the compounds that have antioxidant activity. Quercetin is a flavonoid that has antioxidant activity and protection effect against ulcer. Chlorination of quercetin anhanced the antioxidant. This study aims to obatin the chlorinated derivative of quercetin and examine the protection effect against acetosal-induced gestric ulcer. Chlorination was done by the addition of chlorine at room temperature. Ulcer induction was carried out on rats by oral administration of acetosal. Incidence of gastric ulcer were determined by macroscopic and microscopic observation. Chlorination of quercetin with chlroine gas produced 6-chloroqueretin as major product. The protection effect against acetosal-induced gastric ulcer of this compound was higher than quercatin.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia:20(4):163-169

Penerbit

Yogyakarta : Fakultas Farmasi UGM., 2009

Deskripsi Fisik

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Bahasa

ISBN/ISSN

0126-1037

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

QUERCETIN
STOMACH ULCER

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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