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Optimasi Formula Sediaan Tablet Piroksikam Menggunakan Bahan Flowlac, Avaicel dan Compritol secara Simplex Lattice Design (Optimization of Piroxicam Tablet Formula Using Flowlac, Avicel and Compritol by Simplex Lattice Design Method)

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Piroksikam is non streoid anti inflammation drug (NSAID) with small dose (10-20 mg daily) with a long time (t1/2) elimination. Piroxicam formulation was expected able to yield a good (quality) tablet to physical characteristic standard. Tablet r component was consisted of Flowlac 100 (filler), Avicel PH-101 (binder) and compritol 888 ATQ (lubricant). The research was done with simplex lattice design (SLD) by using 3 component, i.e. Flowlac (A), Avicel (B), and Compritol (C). Seven formula were needed, I,e, FI (100% A), F2 (100% B), and Compritol (C). Seven formula were needed, Ie, F1 (100% A), F2 (100%B), F3 (100% C), 14 (50% A and 50% B), F5 (50% B and 50%C), F6 (50% A and 50% C), dan F7 (33,33% A, 33.33%B, 33.33% C). The optimization parameters of piroxicam tablets were floe rate of the tablet mass, tablet hardness,disintegration time, piroxicam flow rate of the tablet mass, tablet hardness, disintegration time, piroxicam content and the dissolution (C45), on SLD model, equations, contour plots, and superimposed of contour plots were obtained, by which the optimum formula was determined.Based on superimposed contour plot optimum formula was obtained with proportion of flowlac (89.6%), Avicel (7.4%) and Compritol (3%). The result of flowability was 21.46 g/second, hardness (6.45 kg); disintegration time (6.96 minutes); drug content (10.13 mg) and dissolution C45 (7.35 mg) Interaction of flowlac-avicel-Compritol could influence the physical properties and the release profile of tablet. Flowlac was the most do,inant factor in increasing flowability, hardness and dissolution of tablet. Compritol was the most dominant factor in increasing time of disintegration tablet.

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Series Title

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Call Number

Majalah Farmasi Indonesia:20(3):156-162

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2009

Collation

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Language

ISBN/ISSN

0126-1037

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Edition

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Subject(s)

tablets, enteric-coated
RIROXICAM

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