Optimal Pembuatan Granul Ekstrak Herba Seledri (Apium GraveolensL.) dengan Fluidzed Bed Granulator) (Optimization of Celery (Apium Graveveolens L.) Herb Extract Granule Production Using Fludized Bed Granulator) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Optimal Pembuatan Granul Ekstrak Herba Seledri (Apium GraveolensL.) dengan Fluidzed Bed Granulator) (Optimization of Celery (Apium Graveveolens L.) Herb Extract Granule Production Using Fludized Bed Granulator)

Mohammad Djatmiko - Personal Name; Sri Sulihtyowati Soebagyo - Personal Name; Suwijoyo Pramono - Personal Name; Sudibyo Martono - Personal Name;

Celery is an Indonesia herb being used as vegelable and medicinal purposes especially in hypotensive remedy. In order to produce a good quality of celery especially in hypotensive remedy. In order to produce a good quality of celery herb extract granules, a study on the influence of spray rate, level of loctose and Aerosil in influidized bed granulator (FBG) toward hormogeneity, flow rate and water Aerosil in fluidized bed granulator (FBG) toward homogeneity, flow rate and water content of granules was done. In the optimization process was programmed by factorial design, the maximum spray was 4 L/hours and the minimum was 2 L/hours, the maximum amount lactose was 100% and the minimum was 80% of extract weight, and Aerosil content maximal 20% and minimal 0% of extract weight. The oprimum area of optimization result was found superimposed contour plot granule parameters including homogeneity of aplin content, flow rate and moisture content of granules. The result showed that the Aerosil was proven to be disadvantagoeus in FBG process. The optimum area of optimization to obtain good granules was achieved by 2.75 L/hour to 2.00 1/hour of spray rate with the amount of lactose at 93.5% to 100% of extract weight with viscosity at 2.8 cP and density at 1.07 g/Ml and without Aerosil. The granules posseed homogeneity of apiin with CV 3-5%, 0.85-1.00% of water content and 12.0-13.0 g/set of flow rate.

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Location name is not set Majalah Farmasi Indonesia:20(2):84-9091-98

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Series Title: -
Call Number: Majalah Farmasi Indonesia:20( 2)91-98
Publisher: Yogyakarta : Fakultas Farmasi UGM., 2009
Collation: -
Language
ISBN/ISSN: 0126-1037
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Content Type: -
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Edition: -
Subject(s): plants, medicinal
APIUM GRAVEOLENS
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