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Evauasi Biologis Radiofarmaka 99mTc-Rtambutol untuk deteksi Dini Infeksi Tuberkulosis pada Hewan Percobaan (Biological Evaluation of 99mTc-ethambutol for Early Detection Evaluation of 99mTc-Ethambutol for Early Detection of Tuberculosis Infection in Animal Model)

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Tuberculosis (TB) is the single most infectious disease, kllling millions of people globally. Conventional modalities for Tb detection many times the disease is diagnosed at delayed stage and can not use for deep seated infection. Therefore, research and development of 99mtTc-ethambutol to detect and locate TB at an early stage in any anatomical site have been conducted and locate BATAM Bandung. The result of biological evaluation of 99mTc-ethambutol which studed in rat mice are as follow, biodistribution study showed accumulation of 99mTc-ethambutol in thigh with infected Tb at 4 hours post injection via vein with ratio 2,90 target/non target. Blood clearence studies exhibited 44.965 of TC-ethambutol. Renal clearance study exhibited of 79.52% 99mTc-ethambutol administration. Renal clearance study exhibited of 79.52% 9mTc-ethambutol excreted from the urine after 24 hours. The images were acquired with a Gamma-camera at different time intervals 1.2 3 and 4 hours howed localization of the 99mTc-ethambutol in infected TB animal model. This study showed that 99mTc-etambutol is a promises radiopharmaceutical to detect TB infection rapidly and has accurancy with high sensitivity and specificity.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia:20(2):55-61

Penerbit

Yogyakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2009

Deskripsi Fisik

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Bahasa

ISBN/ISSN

0126-1037

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

respiratory tract infections
TUBERCULOSIS
ENTHABUTOL

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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