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Uji Efek Teratogenik Kombinasi Ekstrak Rimpang Jahe Merah dan Ekstrak Buah Mengkudu pada Tikus Wistar (Teratogenicity Study of Combination of Ginger Rhizome extract and Noni Fruit Extract in Wistar Rat

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Ginger Izingiber officinale Roscoe var. Sunti val.) extract in combination with noni (Morinda citrifolia linn) extract has been proven to be efective in tuberculosis patients. To examine its safety in pregnancy condition, the influence of combination ot etanol extract of ginger and ethanol extract of noni fruit had been studied in pregnant Wistar rat. The ginger and noni extract were administered orally at dose level combination of 50 and 50 mg/kg BW, 500 and 500 mg/kg BW, 1000 and 1000 mg/kg BW on day sixth to fifteenth of gestation. The mother was sacrified on day nineteenth of gestation to observe life fetus, resorption, and growfail fetus. One third of the fetuses were hardened with Bouin’s fixation solution. No malformation were found in the eviscerated group. The combination at all doses did not cause any fetus resporption, growth failure and did not cause malformation in organ and skleton. The combination dose of 500 and 500 as well as 1000 and 1000 mg/kg BW caused dark red to black color in the liver of rat fetuses of 7.3 and 8.3% respectively.

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Series Title

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Call Number

Majalah Farmasi Indonesia:20(1): 48-54

Publisher

Surabaya : Puslitbang Farmasi, Badan Litbang Kesehatan., 2009

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ISBN/ISSN

0126-1037

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Subject(s)

plants, medicinal
PERATOGENTS

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