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Sintesis Senyawa Berpotensi sebagai Inhibitor angiogenesis: 2-Benzillden Sikloheksana-1,3-dion (Synthesis of a potential angiogenesis inhibitor compound: 2-benzylldens cyclohexane-1,3-dione)

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Synthesis of an aromatic cyclic enadione, 2-benzylidence-cyclohexane 1,3-dione (a potenstial angiogenesis inhibitor), has been done using benzaldehide (50 mmole) and cyclohexane- 1,3-dione (50 mmole) as starting materials and NaOH 1.0 N as a catalyst. Odorless and white needie-shape powder has been achieved. The power was 252.7 mg (2.53%) and the purity of the powder was 88.81%. Its meiting point was 214.8⁰C. The purity of the product was examined by gas chromathography, while the structure elucidation was done using IR spectrometer,1H-NMR spectrometer, and GC-MS. IR spectrometer showed that the compound had a –c=0 bond conjugated to an alkene or a phenyl moiety, methylen groups, and alkene’s –C-H bonds. 1H-NMR spectrometer showed that the compound had benzene moiety and methylen moieties, which were in α and β position to a carbonyl group. GC-MS showed that the molecular weight of the compound was 200 atomic mass unit.

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Series Title

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Call Number

Majalah Farmasi Indonesia:20(1):1-8

Publisher

Yogyakarta : Fakultas Farmasi UGM,., 2009

Collation

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Language

ISBN/ISSN

0126-1037

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ANGIGENESIS

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