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Ceftibuten Compared to Ciprofloxacin for the Treatment of Lower Respiratory Tract Infection (Pengobatan Infeksi Saluran Napas Bagian Bawah dengan Seftibuten Dibandingkan dengan Siprofloksasin)

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Ceftibuten is a third generation cephalosporine with beta laktamase resistent properties. The drug is a broad-spectrum, oral and allows a single daily dosage which ensures patient compliance. The properties of ceftibuten is compared to ciprofloxacin for the treatment of bronchitis and pneumonia using a clinical trial with a comparative, paralel group, randomized methode. Ceftibuten was given 400 mg once daily and ciprofloxacin was given 500 mg twice daily for 5-10 consentive days. The results showed from 32 patients, 2 were available for evaluation; 19 received ceftibuten and 10 received ciprofloxacin. The effectivity of both groups were almost identical, for bronchitis the effectivity was 95 percent ceftibuten and 90 percent for ciprofloxacin, for pneumonia the effectivity for ceftibuten was 89 percent and ciprofloxacin 100 percent. The side effect of both drugs were not prominent-10 percent for ceftibuten, 16 percent for ciprofloxacin. The advantage of ceftibuten among others is increased patient compliance.

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Majalah Kedokteran Indonesia,45(4)1995:236-241

Publisher

: ., 1995

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Subject(s)

respiratory tract infections
ciprofloxacin

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