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Sub Chronic Test From Alkohol Extract Paliasa Leaves (Klenhovia Hospital Linn) to Hepar/Liver and Kidney of Experimental Mice

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Paliasa leaves used to be a traditional medicine for hepatic/ lever desease, so need to maintain the secure & health from the user of this medisine, the aim of the research is to find the dava of ub chronic toxicity from 70% alcohol extract paliasa leaves for experimental mice. The research use amont 30 of 40 months white male mice wistar strain which have weight in average (SD) about 208,75 ± 17,47 gr. The extract was given by oral through the spuit for 12 weeks (3 months) for every mice. After that, all of mice had been killed by ether liquid, and for histologi examination, the blood had been taken from the mice’s heart, liver & kidney. The research had been conductwith completed random design includes 5 treatments & 6 repeats. Each treatment included give mice aquades with dosage 0 mg/kg body weagth (control) for 1st group paliasa leaves estract with dosage 250 mg/kg body weight for 2nd group, 3nd group with dosage 500 mg/kg body weight, 4th group with dosage 750 mg/kg body weight & for 5th group with dosage 10000 mg/kg body weight SGOT, SGPT, Bilirubin direct & indiret, creatinin, ureum kidney & liver cell destruction had been measured from all of groups. The result shows that from eight parameters in statistically, there are no significant differences between each treatment. The conclutionis paliasa leaves extract still save in very treatment dosage.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Media Penelitan dan Pengembangan Kesehat:19(4):209

Penerbit

Jakarta : Badan Litbang Kesehatan., 2009

Deskripsi Fisik

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Bahasa

ISBN/ISSN

0853-9987

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Tipe Media

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