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49.4 Kda Outer Membrane Protein of Porphyromonas gingivalis is a Hemaglutinin and Adhesin Protein to Neutrophil

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Peridontitis is caused mostly by P. Gingivalis and it is related to acute coronary syndrome. P. Gingivalis readily invades into blood circulation and potentially induces collagenolytic activity of neutrophil which result in collagen vascular degradation lead to atheroscletoric plague rupture (APR). APR is responsible for accuring fatal cardiovascular events such as acute myocardial infarction (AMI). These information brought out notion concerning the adhesion interaction of P. Gingivalis with neutrophil. The aim of this study was to assess adhesion molecule of P, gingivalis outer membrane protein (OMP) by partial characterization took in hemaggulation assay using mice erythrocytes, adhesion inhibition assay by gradual concentration of adhesion blocked in neutrophil ,immunologic assay using Western-blotting and immunocytochemistry. The results showed that 49,4 kDa P. Pingivalis OMP can agglutinate mice erythrocytes and adherence to netropil. Increase concentration of 49,4 kDa OMP of P. Gingivalis reduce adhesion process to netropil. This protein was recognized by polyclonal antibody of 49,4 kDa adhesion molecule. It can be concluded that P. Gingivalis membrane protein is a hemagglutinin and an adhesion molecule to netropil.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya:25(2):49-59

Penerbit

Malang : Fakultas Kedokteran Universitas Taruma Negara., 2009

Deskripsi Fisik

11p.

Bahasa

ISBN/ISSN

0216-9347

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

HEMAGLUTIMATION
POPHYROMUNAS GINGVALIS
ADHERIANS

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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