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Oral Concumption of Combined Vitamin C and E Repair Liver Damage Due to Subchronic Cigarette Kretek Exposure

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Free radicals in Cigarette smoke can destroy tissue and cells of the body. The activity of free radicals can be reduced by antioxidants from external and internal. The objective of this research is to investigate the effects of vitamin C and vitamin E combination on the histopathology or rat liver exposed by subcronic cigarette smoke. This research using true experimental study with post test only control group design. The sample of this research we used 32 Wistar rats, ages 2-3 months, weight 150-200 grams divided into 8 groups. Cigarette smoke exposed for 10 weeks. The target of this study is to the number of liver cells damage ((Necrosed hepatocytes). Data analysis using One-Way ANOVA followed by Turkey test. The result show the number of necrosed hepatocytes are significantly decrease. This study consluded that combined vitamin c dose 0,2 mg/g of BW and Vitamin E dose 0,04 IU/g of BW could decrease the number of necrosed hepatocytes in rats.

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Series Title

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Call Number

Jurnal Kedokteran Brawijaya: 25 (1): 23-27, 2009

Publisher

Malang : Fakultas Kedokteran Universitas Brawijaya., 2009

Collation

5p.

Language

ISBN/ISSN

0216-9347

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

VITAMIN E
TOBACCO SMAKE POLLUTION
AGCARBID ACID
HEPATOCYTES

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Statement of Responsibility

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