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Local Propolis Extract Has Cytotoxic and Antiproliferative Effect on HeLa Cells

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Propolis is resin with complex chemplex chemical composition that collected by honeybees from various plants. It has been known that propolis has several biological properties, such as antimicrobial, anti-inflammatory,antioxidant and immunomodulatory activities. The aim of this study is to evaluate the proporlis’s cytotoxic and antiproliferative activity in vitro on hela cell line. These cells were incubated with different concentrations of propolis (5,10,25, 50, and 100 µg/ml) for different time periods (6,24, dan 48 hours), and the number of viable and died cells were analyzed by trypan blue dye exclution and were counted using hemocytometer. The result of this study showed that the IC50 of local propolis against HeLa cell line is 27,725 µg/ml. It can be concluded that local propolis extract exhibited a cytotoxic and antiproliferatif affect in vitro against HeLa a cell line, in a dose-and time dependent.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya:25(1): 17-22

Penerbit

Malang : Fakultas Kedokteran Universitas Brawijaya., 2009

Deskripsi Fisik

10p.

Bahasa

ISBN/ISSN

0216-9347

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

propolis
HELA CELLS
CYTOTOXINS

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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