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Local Propolis Extract Has Cytotoxic and Antiproliferative Effect on HeLa Cells

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Propolis is resin with complex chemplex chemical composition that collected by honeybees from various plants. It has been known that propolis has several biological properties, such as antimicrobial, anti-inflammatory,antioxidant and immunomodulatory activities. The aim of this study is to evaluate the proporlis’s cytotoxic and antiproliferative activity in vitro on hela cell line. These cells were incubated with different concentrations of propolis (5,10,25, 50, and 100 µg/ml) for different time periods (6,24, dan 48 hours), and the number of viable and died cells were analyzed by trypan blue dye exclution and were counted using hemocytometer. The result of this study showed that the IC50 of local propolis against HeLa cell line is 27,725 µg/ml. It can be concluded that local propolis extract exhibited a cytotoxic and antiproliferatif affect in vitro against HeLa a cell line, in a dose-and time dependent.

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Detail Information

Series Title

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Call Number

Jurnal Kedokteran Brawijaya:25(1): 17-22

Publisher

Malang : Fakultas Kedokteran Universitas Brawijaya., 2009

Collation

10p.

Language

ISBN/ISSN

0216-9347

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Media Type

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Carrier Type

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Edition

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Subject(s)

propolis
HELA CELLS
CYTOTOXINS

Specific Detail Info

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