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The Development of Allergic Mouse Model Following Chronic Ovalbumin Exposure

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Histology expression in asthma show inflammatory processes and airway structural changes. Treatment development in asthma needs appropriate animal models but most animal models use short term allergen exposure. The aim of this research was to create an allergic mouse model with allergic inflammation and structureal changes histology expression. Eight female BALB/c mice, 6-12 weeks old, 80-100 grams were devided into groups. The first group were exposed to a normal saline solution where the second group received ovalbumin. Mice were sensitilized by intraperitoneal injection of avaibumin on Day 0 and 14 and chellenged by nebulization of 1% ovaibumin three weekly for 6 weeks. Twenty fours after final exposure, the mice were sacrificed by lethal cardiac puncture. The level of total IgE in serum were measured by EISA and IL-4 receptor expression were examinated by immunohistochemistry. Morphometric analysis was performed to count inflammatory cels, eosinophil, goblet cells, epithel and smooth muscle thickness. Differences betwen the control and exposed mice were analyzed by Mann-Whitney test. There were a significant differences in total IgE serum expression IL-4 receptor between the two groups (P

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kedokteran Brawijaya:25(1): 1-5

Penerbit

Malang : Fakultas Kedokteran Universitas Brawijaya., 2009

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

0216-9347

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

asthma
RATS-diseases
OVALBUMIN
HYPERTENTIVITY

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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