The Effect of Cadmium Chloride Injection through the Fetal Development and Histological Change of the Liver and Kidney of the Pregnant CBR Strain Mice (Pengaruh Penyuntikan Kadmium Klorida terhadap Perkembangan Fetus serta Organ Hati dan Ginjal Mencit (Mus musculus L.) Strain CBR) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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The Effect of Cadmium Chloride Injection through the Fetal Development and Histological Change of the Liver and Kidney of the Pregnant CBR Strain Mice (Pengaruh Penyuntikan Kadmium Klorida terhadap Perkembangan Fetus serta Organ Hati dan Ginjal Mencit (Mus musculus L.) Strain CBR)

Sunityoso, Sumitro - Personal Name; Rafaih, Ratu Siti - Personal Name; Kusmana, Dadang - Personal Name;

A study of the effect of a single dose injection of CdCl2 solution (2.5, and 3.5 mg CdCl2/kg of body weight) on fetal development and histological changes in liver and Kidney of the 7th day pregnant mice (Mus musculus L.) was conducted. Observations were made on the 18th day of pregnancy. Statistical analysis, using Kruskal-Wallis test, indicated that there were no significant differences (y=0.05) on the precentage of implantation failures, fetal weight and length between control and treated animals. Post implantation mortality and external morphologic malformations of the fetuses increased with the increase of the dose (Jonckheers-Terpstra test, y=0.05). Morphological deviations, such as hematoma, placental fusion, growth inhibitions, were also found on the treated animals. Kruskal-Wallis test also showed that there was a significant difference (y=0.05) of polydactily of the fore extremities between control and treated animals. However, the same effect was not found on excencephalic malformations. Histological examination of liver tissues of treated animals showed dilations of the central vein, cytolysis and fat accumulation. In kidney tissues, glomerular constrictions and increasing distance between two Bowman capsule walls were clearly observed. The level of liver and kidney damage apparently increase with the increase of CdCl2.

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A00000290

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Series Title: -
Call Number: Majalah Kedokteran Indonesia,45(12)1995:692-699
Publisher: : ., 1995
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Subject(s): cadmium
rat
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