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Genetics of Graves Disease: The Lost Concept

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A key issue of Really Significant Genes (RSG) that caused Graves Disease in unresolved. RSGs are considered likely major contributors to genetic risk for a disease. These genes should be strongly linked within families and they could become clinically useful as predictor of disease. Some Graves Disease susceptibility genes have been identified. The first identified was the Human-Leucocyte-Antigen DR (HL-DR) gene locus, then a non-HLA genes as cytotoxis T lymphocyte antigen (CTLA-4), CD40, protein tyrosine phosphatase-22 (PTPN22), thyroglobulin, and thyroid-stimulating hormone receptor (TSHR) gene. The sites observed in different populations were not always the same. With the completion of the HapMap, which provided the geography of thousands single mucleotide polymorphisms (SNPs), the search of more minor associated genes stated again although studies never revealed stronger candidates, meanwhile, the role of the environment in disease development remains poorly understood. The importance of the environment with the mechanisms involved including genetic factors is needed to be decided.

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Ketersediaan

Tidak ada salinan data

Informasi Detail

Judul Seri

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No. Panggil

Acta Medica Indonesiana, 41(1): 37-40

Penerbit

Jakarta : RS. Cipto Mangunkusumo., 2009

Deskripsi Fisik

4p.

Bahasa

English

ISBN/ISSN

0125-9326

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

GREVES DISEASE

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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