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The Hepatoprotective Properties of Shallot (Allium ascalonicum L.) for CCl4 Intoxicated Rats by the Inhibition of Free Radical Formation (Daya Hepatoprotektif Bawang Merah (Allium ascalonicum L.) terhadap Efek Destruksi Radikal Bebas pada Tikus Keracunan CCl4)

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Shallot (Allium ascalonicum L) is widely used as spices. We have demonstrated previously that garlic and leek, both are also from the Allium genus, could protect rat liver againts CCl4 intoxication. In this paper was report the hepatoprotective properties of shallot. Eighteen Wistar rats, male, 3 months old were divided randomly into three equal groups. The first group received only a standard diet. The second group was intoxicated orally with 0.55 mg CCl4 body weight in single dose. The third group received a pretreatment with water extract of shallot, given orally in a daily dose of 20 g/kg body weight, eight days successively. Two hours after the last pretreatment, rats of the third groups were intoxicated with CCl4 in a same dose as the second groups. Rats were sacrified 48 hours after CCl4 intoxication. GPT activity in plasma and lipid peroxide content in liver were assesed in each animal. The results indicated that both parameters increased significantly in the second group, while in the two other groups its values were practically identical. We conclude that shallot should contain substance(s) which protected the rat liver against free radical formed during CCl4 intoxication.

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Majalah Kedokteran Indonesia,45(12)1995:680-684

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: ., 1995

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plant extracts

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