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Laju Disolusi Suppositoria Asetosal dalam Basis PEG 400 dan PEG 4000 dengan enambahan Crospovidone 2% dan 5%
The ogjective of this was to investigate crospovidone concentration (2% dan5%) to dissolution rate of acetosal suppository base that used was mixture of PEG 400 and PEG 400 (40.60). Hanson Research Disolution Tester used to determine dissolution rate. After 5; 15; 30; 45 and 60 minutes, respectively sample taken and assay done by HPLC. Efficiency dissolution for formula 1 and formula II was 71.82% and 68.72% respectively. Analysis statistics by t test indicated that there was significancy between suppository that contained crospovidone 2% and 5%
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