Percakapan Silang Reseptor Steroid (Steroid Receptor Cross Talk) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Percakapan Silang Reseptor Steroid (Steroid Receptor Cross Talk)

Paul S. Poli - Personal Name;

The goals of this miniview are: Firstly, to know that the cross-talk may be defined as a functional interaction between two (or more) signaling pathways. And also cross-talk may involve different steps of the pathways. Some signaling molecules are able to bind to and activate different nuclear receptors. In addition, some ligands may be be agonist of a given nuclear receptor and antagonist or inverse agonist of another receptor. Secondly, to understand that cross-talk may result from the possibility that target gene products (enzymes) of a given pathway may affect the chemical integrity and therefore the functionally of ligands/activators of a receptor controlling another pathway. This dynamic behavior offers interesting possibilities for cross-talk between the receptor and interacting pathways. Many signaling cascades can rapidly modify a given response at genomic targets. Thirdly, in related to cross talk among the steroid hormones can act as chemical messengers in a wide range of species and target tissues to produce both slow genomic responses, and rapid non-genomic responses. Thereby the fungtional crosstalk between steroid receptors and tyrosine-kinase receptors of the other steroid hormone such as estrogen, progesterone, corticosteroid accurs in both the cytoplasm and nucleus of steroid-dependent cells. These interactions may allow for therapeutic manipulations of steroid-dependent cells. These interactions may allow for therapeutic manipulations of specific pathways, perhaps equally effectively for treatment of steroid-dependent or steroid-dependent cancers arising from these cells.

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Series Title: -
Call Number: Majalah Ilmu Faal Indonesi,7(3):220-224
Publisher: Surabaya : Ikatan Ahli Ilmu Faal Indonesia., 2008
Collation: 3p.
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ISBN/ISSN: 0215-1995
Classification: -
Content Type: -
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Edition: -
Subject(s): STEROID, RECEPTORS
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Statement of Responsibility: -

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