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Peran Endocannabinoid dalam Pengaturan Nafsu Makan )Role of Endocannbinoids in Appetite Regulation)

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Physiological basis for the actions of plantderived cannabinoids has been explained has been explained by the discovery of two cannabunoid receptors and the their endogenous ligands, the endocannabinoids The substances include anandamide, 2-arachidonoyl glycerol (2-AG), noladin ether, NADA and virodhamine. The encocannabinoid receptor (ECBR) system ilfluences energy balance and food intake at four different levels: hedonic evaluation at the limbic system level, modulation intergrative functions of feeding behavior within the hypothalamus and hindrbrain and periphereally, in the intestinal system and adipose tissue. The drug significantly increase intake, elevated hunger ratings and enhanced food appreciation. Clinically, THC (dronabinol) which is psychoactive compound of cannabinoids used to combat a reduction in appetite and consequent reduction and wasting, whereas the antanonist receptor of cannabinoid 1 (CB 1 receptor), rimonabant used to reduce food intake and adiposity in patient with abesity rnrn

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Detail Information

Series Title

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Call Number

Majalah Ilmu Faal Indonesia, 7(2): 131-137

Publisher

Surabaya : Ikatan Ahli Ilmu Faal Indonesia., 2008

Collation

4p.

Language

ISBN/ISSN

0215-1995

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ENDO CANNABINOIDS
APPETITE REGULATION

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