The Differences of Apoptotic Trophoblast Cells of Normal Pregnancy and Pre Eclampsia/ Eclampsia | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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The Differences of Apoptotic Trophoblast Cells of Normal Pregnancy and Pre Eclampsia/ Eclampsia

Kusnarman Keman - Personal Name; Nugrahanti Prasetyorini - Personal Name; Madeline J. Langgar - Personal Name;

Hypoxia exposed trophoblast cells will cause apoptotic process, that correlate with up-regulation of p53 and Bax protein expression; and down-regulation of anti-apoptotic Bcl-2; also find both on trophoblastic sample from preeclampsial eclampsia complicated pregnancy, and normal pregnancy. The aim of this study is, to prove that the amount of apoptotic trophoblast cells on trophoblast tissue sample from preeclampsial acclampsia complicated pregnancy, were higher then those of normal pregnancy. This research was laboratory cross sectional study , that observed immunohystochemically, p53 and BCL-2 protein expression; also the DNA-fragmented technically (TUNEL) to detect apoptotic cells on trophoblastic samples from preeclampsial aclampsia complicated pregnancy, compare by the normal pregnancy. On this study, we found that the amount of trophoblast cells that expressed of p53 protein (22.70±2.90), were higher then those of normal pregnancy. (8.2±4.99). The different was statistically significant. (t test; p d”0.000). We also found that an apoptotic process on trophoblast cells of preeclampsial eclampsia placenta (15.3±3,56) were higher then those of normal pregnancy (4.7±1.89). The different was statistically significant. (t test; p d”0.000). While the amount of trophoblast cells expressed of Bcl-2 protein, were higher on trophoblast tissue sample from normal pregnancy (20.3±5.77) then those of preeclampsial eclampsia (9.9±1.91). The different was statistically significant. (t test; p d”0.000). This finding conclused, that the amount trophoblast cells that were apoptotic on trophoblast tissue of preeclampsial eclamsia complicated pregnancy, were higher then those of normal pregnancy. rnrn

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Series Title: -
Call Number: Jurnal Kedokteran Brawijaya, 24(2): 79-85
Publisher: Malang : Fk. Universitas Brawijaya., 2008
Collation: 4p.
Language
ISBN/ISSN: 0216-9347
Classification: -
Content Type: -
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Edition: -
Subject(s): pre-eclampsia
APOPTOSIS
ECLAMPSIA
TROPHOBLASTS
Specific Detail Info: -
Statement of Responsibility: -

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