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Characteristic of a Specific Monoclonal Antibodies against the Surface Coat of Infective Stages of Brugia malayi Larvae (Karakterisasi Antibodi Monoklonal Spesifik Selubung Larva Stadium Infektif Brugia malayi)

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is an important public health problem in Indonesia. A diagnosis of filariasis in normally based on clinical, parasitological and immunological examinations but the methods have limitations. There is an urgent need to improve for malayan filariasis using monoclonal antibodies to defect circulating antigen. Recently, many types of monoclonal antibodies have been prduced following immunization of mice with various stages of filarial antigens. Those monoclonal antibodies have different characteristics. The objective of this study was to explore the characteristic of specific monoclonal antibodies against the of infective stages of larvae. This monoclonal antibody recognized antigen of 40.000 MW protein which is present among the antigens of surface coat of Brugia malayi larvae, as detected by an . classification using ELISA techniques indicates that those antibodies are IgG2b and IgG3 subclasses. In addition, these antibodies also demonstrate a low level reactivity with surface antigen of Brugia pahangi, Ascaris lumbricoides and hookworm.

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Berkala Ilmu Kedokteran,27(3)1995:159-164

Publisher

: ., 1995

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antibodies, monoclonal
filariasis

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