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The Effect of Interferon on Multiple Myeloma Therapy (Peranan Interferon pada Multipel Mieloma)

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Multiple myeloma (MM) is a neoplasm of mature and immature plasma cells. The clinical manifestation of this disorder results from the uncontrolled and progressive proliferattion of these cells, the effect of marrow replacement, and the over production of M-component. The incidence is varies and rise with age. In the last five years, in Hasan Sadikin Hospital-Bandung, we found thirty seven cases only. The diagnosis of MM based on Durie-Salmon criteria, consist of major and minor criteria. The prognosis is profoundly influenced by a number of factors, especially the stage of the disease at the time of diagnosis. The gold standard for myeloma treatment is still Melphalan-Prednisons. Previous randomized control trials using a combination chemotherapy have not shown any improvement in a response rate, although there were slight increased in overall survival times. Interferon (IFN) has been evaluated in many settings for the treatment of MM. In the study by Mandelli duration of survival was improved in the IFN treated group compared with other combination chemotherapy without IFN, the difference appear to be statistically significant (p=0.05). Our interm results of myeloma patients treated with melphalan-prednison plus IFN will be pressented and similarly have the same results with study by Mandelli. Several well-described side effect have been known to occur almost universally in healthly subjects and cancer patient. The most common acute adverse effect in flue-like syndrome. This toxicity is dosage related, in general IFN are well tolerated for prolonged periods when given is a dosage between 1-5 million units daily. In conclusion, although further studies are needed to clarify the role of IFN in the management of MM, IFN does appear to be benefecial.

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Majalah Kedokteran Bandung,27(2)1995:51-56

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: ., 1995

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interferon
myeloma

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