The Thyroxine Binding Globulin Consentration in Molar Pregnancy Compare with the Normal Pregnancy (Kadar TBG ('Thyroxine Binding Globulin') pada Molahidatidosa Dibanding dengan pada Kehamilan Normal) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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The Thyroxine Binding Globulin Consentration in Molar Pregnancy Compare with the Normal Pregnancy (Kadar TBG ('Thyroxine Binding Globulin') pada Molahidatidosa Dibanding dengan pada Kehamilan Normal)

Kariadi, Sri Hartini KS. - Personal Name;

One of the changes that involves thyroid metabolism and function in normal pregnancy as well as in molar pregnancy is the increase of TBG (thyroxine binding globulin) concentration which may cause misinterpretation of thyroid function. The aim of this study is to evaluate the TBG concentration in molar pregnancy in comparison with that in the normal pregnancy. The study was concluded using the cross sectional method with comparative observational analysis. The observation subjects were 37 with molar pregnancy (molar group) and 38 with first trimester normal pregnancy (non-molar group), sampled through sampling from consecutive admissions from patients treated in the Department of Obtetrics and Gynaecology, Hasan Sadikin Hospital, TBG concentration was measured by enzyme-linked immunoassay. In the molar group the mean TBG concentration is higher than normal (non-pregnant level), 22.66 (7.43 ug/L, there is no significant difference between group of 8, 10 or 12 weeks of pregnancy (x= 0.447, p=0.800). There is no correlation between TBG concentration and uterine size (r=-0.001; p more than 0.005). In the non-molar group the mean TBG concentration is within normal limits, 14.05 (10.04) ug/L, there is no difference between pregnancy age groups (x2=1.252; p=0.74. In comparison, the mean TBG concentration of the molar group is higher than the non-molar group (Z=0.18; p less than 0.001). From this study we may conclude that the mean (TBG concentration in molar pregnacy is higher than non-pregnant normal level and is higher than that of first trimester normal pregnancy. There is no correlation between TBG concentration with age of pregnancy or with the uterine size.

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Series Title: -
Call Number: Majalah Kedokteran Bandung,27(1)1995:27-30
Publisher: : ., 1995
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Subject(s): pregnancy
thyroid hormones
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