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The Role of (+) Cyanidanol-3 in Liver Protection Against Toxic Effect of Paracetamol a Histological Study (Peranan (+) Cyanidanol-3 untuk Melindungi terhadap Toksisitas Hepar Akibat Parasetamol Suatu Kajian Histologis)

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Paracetamol has been widely used against fever and acts as an analgesic. This drug, however, could be hepatotoxic and nephrotoxic. Many hepatoprotector drugs have been used to prevent against liver damage, through they showed no convincing results. (+) Cyanidanol-3 was reported to be able to prevent the permeability of liver cell membrane. This experiment was design to study the role of (+) Cyanidanol-3 in preventing liver cells against toxic effect of paracetamol. Thirty six Rattus norvegicus weighing 150-180 g were used and divided into 4 groups, each group contains 9 animals. Group 1 was a control; group 2 was given 8 g/kg body weight (+) Cyanidanol-3; group 3 and 4 were given 500 mg/kg body weight paracetamol and 500 mg/kg body weight paracetamol plus 8 g/kg body weight (+) Cyanidanol-3, respectively. All rats were sacrificed at 6, 12 and 24 h after treatment, and the liver tissues were collected. These tissues were prepared for histological examination using parafin methode and stained with Hematoxilin-Eosin. The results showed that both groups which received paracetamol and (+) Cyanidanol-3 and the group that received paracetamol only, produced similar liver damage as a result of toxic effect of paracetamol.

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Jurnal Kedokteran Yarsi,3(3)1995:25-37

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: ., 1995

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catechin

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