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Expression of HBsAg and HBcAg in Liver Biopsy Speciments of Chronic B Hepatitis Patients and its Relation with Histology Activity Index

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The assess the relationship between Histology Activity Index (HAI) and the expression of HBsAg and HBcAg. Thirty liver biopsy specimens of chronic B hepatitis patients have been examined. Expression of HBsAg and HBcAg were determined by immunoperoxidase stanning. HAI was calculated according to Knoldell's method. All of the specimens (29) were positive for HBsAg and HBcAg staining. Regular-uniform distribution patterns of HBsAg were found in 3 specimens and irregular non-uniform patterns in 26 specimens. Regular-uniform patterns of HBcAg were found in 4 specimens and the irregular non-uniform patterns in 25 specimens. HBsAgs 1 + were seen in all specimens which have HAI range of 1 to 18. Cytoplasmic/membraneous HBcAgs were seen 1 + in 20 specimens, 2 + in 3 specimens, and 3 + in 6 specimens. HAI of each group which showed HBcAg was not significantly different. HBcAgs in the nuclei of liver cells were seen 1 + in 14 specimens, and 15 specimens were negative. HAI of each of these groups showed no significant differences. HAI of regular-uniform distribution pattern groups of HBsAg and HBcAg were not significantly different from HAI of irregular non-uniform groups. Expression of HBsAg and HBcAg in liver biopsy specimens of chronic B hepatitis patients are not correlated with necroinflammatory activity.

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Medical Journal of Indonesia,5(3)1996:142-148

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: ., 1996

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hepatitis B surface antigens
hepatitis B core antigens

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