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The Role of Hemodialysis Duration on the Evolution of Lipid Profile in Chronic Renal Failure Patients with Hemodialysis (Pengaruh Lama Hemodialisis terhadap Profil Lipid Penderita Hemodialisis Kronik)

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A follow-up study was conducted at Renal Unit Sardjito Hospital Yogyakarta Indonesia, between November 1992 and November 1994 to determine the role of hemodialysis duration on the evolution of lipid profile in chronic renal failure patients with hemodialysis. Considering abnormal levels of HDL-cholesterol of less than 45 mg/dl and Apo-A1 less than 165mg/dl, at baseline, we found abnormal mean HDL-cholesterol levels both in male (33.94 mg/dl) and female (39.50 mg/dl) groups, and mean Apo-A1 levels both in male (86.44 mg/dl) and female (101.56 mg/dl) groups. Apo-A1 levels male group was significantly lower than in female group (86.44 plus/minus 17.19 mg/dl vs 101.56 plus/minus 13.28 mg/dl, p less than 0.05). After two years of follow-up 32 patients died, 2 underwent kidney transplantation, and 8 were removed or lost the follow-up, eventually 19 patients were able to analyzed. There was a significant increase of triglyceride levels in female group (192.40 plus/minus 21.31 mg/dl to 244.80 plus/minus 18.22 mg/dl, p less than 0.005), significant decrease of HDL-cholesterol levels both in male (35.85 plus/minus 13.20 mg/dl to 28.28 plus/minus 21.27 mg/dl, p less than 0.05) and female (41.80 plus/minus 10.05 mg/dl to 27.00 plus/minus 5.87 mg/dl, p less than 0.05) groups, and significant increase of total-cholesterol/HDL-cholesterol ratio in female group (4.84 plus/minus 1.28 to 7.08 plus/minus 2.37, p less than 0.05), after two years of follow-up. The conclusion that its abnormal levels of HDL-cholesterol and Apo-A1 level are already present both in male and female, and Apo-A1 in male is significanty worse than female at baseline. Although there are no consistent changes in lipid levels, after two years of hemodialysis, thera are a significant worsening of HDL-cholesterol levels and total-cholesterol/HDL-cholesterol ratio both in male and female, and triglyceride levels in female.

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Medika,22(9)1996:692-696

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: ., 1996

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lipids
hemodialysis
kidney failure, chronic

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