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Inhibition Effects of Curcumin and its Analogues on Liver Glutathione S-Transferses Activity of Rats (Efek Hambatan Kurkumin dan Analognya terhadap Aktivitas Glutation S-Transferase Liver Tikus secara in Vitro)

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Plant phenols have been reported to have inhibitory effects on glutathions S-transferase (GST) activity when 1-chloro 2,4-dinitrobenzene (CDNB) is used as a work was aimed to study on the effects of curcumin and its analogues on liver GST activity of phenobarbital and Betha-naptoflavone-treated rats. The product of the inhibition of GST-activity on the conjugation reaction between glatathione and CDNB by curcumin and its analogues was measured spectrophotometrically. The IC50 (concentration of inhibitor resulting in 50 inhibition) values found were: Curcumin (3):GST-N (2.8 uM); GST-PB (10.0 uM) and GST-BNF (20.6 uM). Curcumun (14): GST-N(105 uM); GST-PB (20.4 uM) and GST-BNF (37.9 uM). GST iso enzyme from cutosol fraction of rat liver can be induced by phenobarbital and Betha-naphtoflavone, that exhibited the increasing of V max values when compared with control. Based on the IC50 and Ki values, it was suggested that curcumin (3) has a stronger in vitro inhibition potency on GST-activity than its analogues (i.e. curcumin 14).

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia,7(1)1996:39-51

Penerbit

: ., 1996

Deskripsi Fisik

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Bahasa

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

curcumin
transferases

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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