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Induction of Saccharopolyspora erythea ATCC 11635 to Increase its Tolerance through the Palm Oil as a Pre-Precursor of Erythromycin Biosynthesis (Induksi Saccharopolyspora erythrea ATTCC 11635 untuk Meningkatkan Toleransinya terhadap Minyak Sawit sebagai Pra-Prekursor Biosintesis Eritromisin)

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Study of palm oil additions with different concentrations during the adaptation phase for increasing the erythromycin production of Saccharopolyspora erthrea in shaken cultures resulted that the best erythromycin production was given by the addition of 3 percent plam oil. In the fermenter scale, addition of 3 percent palm oil during the adaptation phase yielded the erythromycin-production increase about 500 percent higher than that of the control; while the addition during exponential phase the erythromycin-production increase was about 1,100 percent higher than that of the control. In the shaken culture, 0.25 percent palm oil induction of the erythromycin producer, S. erythrea, did not increase the microbes tolerance against lipid; however it gave a better erythromycin-production increase, that was araound 1,600 percent higher than that of the control.

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Majalah Farmasi Indonesia,7(1)1996:1-10

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: ., 1996

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plant oils
saccharopolyspora

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