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BCG Revaccination for the Prevention of Tuberculosis (Vaksinasi Ulang BCG dalam Pencegahan Tuberkulosis)

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The use of BCG vaccine has been controversial for decades, however BCG is the most widely used vaccine in the world. There are different policies regarding the use of BCG in different countries and region of the world, with different vaccine preparation. Where BCG is used, the vaccine is most commonly administered at birth or in the first of life, and in some regions, multiple revaccinations have been administrered throughout childhood and adolescence. The protective benefit was found to be exitremely variable. In some programe, negative tuberculin skin tests have been used as indicator for the need to revaccinate with BCG. However, there is a poor correlation between skin tests conversion rates or size of induration and protective immunity. The risk of administering BCG vaccine to persons with positive tuberculin reactions due to either prior BCG vaccination of natural infection is minimal. There is no definitive evidence that repeated BCG vaccination confers additional protection against tuberculosis. Although BCG vaccine is relatively inexpensive, the administration of BCG vaccine after the first year of life or giving repeated vaccination may occur significant additional cost and is probably not cost effective and difficult to study. Rapid case detection and effective treatment remain the highest priorities for the control of tuberculosis in all countries.

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Majalah Kedokteran Indonesia,46(7)1996:394-398

Publisher

: ., 1996

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Subject(s)

TUBERCULOSIS
bcg vaccine

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