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The Role of Skin Immunity against Infections: Special Reference in Atopic Dermatitis Patients (Peranan Sistem Immunitas Kulit terhadap Infeksi: Bahasan Khusus pada Penderita Dermatitis Atopik)

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Defence mechanism can be divided in two kinds of mechanism. The first is non specific and the second is specific mechanism. The first mechanism based on the non specific activities which mediated by macrophages and the second mechanism based on the activities of the immunocompetent cells and its effectors which consists of T cells, antibodies, cytokines and or interleukins. In nature there is strong that these kinds of mechanisms were closely related since the phagocytes act as phagocytic cells in the non specific mechanism but on the other hands it also could act as an antigen presenting cells in specific mechanism. Among atopic dermatitis patients (AD) it had been noted that there is evidence of the partially T-cell defect among them. In the dermal compartment, the cooperations among keratinocytes, epidermal Langerhans cells (LC) and T lymphocytes generates immune responses after antigenic stimulations. An antigen captured by dermal dendritic cells (DDC) or epidermal langerhans cells (LC) will be followed by migration of these cells from epidermis to the dermal linfonodus via endothelial epithelium and stimulates the immune responses. Bacterial invasions became easier to spead that caused by the failure of intracellular killing process.

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Majalah Kedokteran Indonesia,46(7)1996:365-372

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: ., 1996

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dermatitis, atopic

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