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The Effect of Intraperitoneal Curcuminoid Hepatoprotector on Rat's Heart with Paracetamol Toxic Dose (Efek Hepatoprotektor Kurkuminoid Intraperitoneal pada Hati Tikus yang Terpajan Parasetamol Dosis Toksik)

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We have performed a study on the effects of curcuminoid on liver damage induced by paracetamol in the rat. The present experiment was designed to find out whether the protective effects of curcuminoid was not mediated by inhibition of drug absorption in the intestine. The study was carried out on 4 groups of rats, consisting of 5 rats each; curcuminoid was administered intraperitoneally to group B; C and D : 20 mg/kg BW; 10 mg/kg BW and 2.5 mg/kg BW respectively at 1, 7, 22, 28 and 46 hours after the administration of paracetamol 2,500 mg/kg BW P.O. Group A was given only paracetamol 2,500 mg/kg BW and saved as the control group. Fourty eight hours after the administration of paracetamol the rats were sacrified by means of decapitation after an ether anesthesia. The livers were excised, weighed and fixed in a 10 percent buffer-formaldehyde solution, and were processed according to the histopatological procedure. Results were analyzed by means of one-way ANOVA and Kruskal-Wall is with a level significancy of p less than or equal to 0.05. Our results that the administration of a dispersible curcuminoid did not reduce the SGOT and SGPT concentration. The histopathological data in group C (1.8 plus minus 0.4) and D (1.6 plus minus 0.4) shows mostly better than control group (3.4 plus minus), but it was not significantly different. The protective effects of curcuminoid on live managed induced by paracetamol in the rats seemed not to be medicated by the inhibition of paracetamol in the intestine.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmakologi dan Terapi Indonesia,12(1)1996

Penerbit

: ., 1996

Deskripsi Fisik

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Bahasa

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

curcumin

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Pernyataan Tanggungjawab

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