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Comparison between Albendazole and Pyrantel Pamoate Once and Twice Yearly in Urban Slum School Children in Ujung Pandang

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This study examined the comparison between pyrantel and albendazole, in terms of their effectiveness by once and twice yearly in school-age children. School children (n=507) were assigned randomly to four anthelminthic groups (pyrantel once or twice : albendazole once or twice) and a placebo group, according to gender and Ascaris lumbricoides eggs counts. Children received single doses of either pyrantel, albendazole, or placebo at baseline and again at 6 mo. The prevalence and intensity of Ascaris lumbricoides and Trichuris trichiuria infections were determined at baseline, 3, 6, and 12 mo. No differences were found between the five groups at baseline in prevalence and intensity of both infections. At 12 mo, the intensity of both infections was greatly reduced in the dewormed groups (P less than 0.001) and reduced slightly in the control group (less than 0.05). Both pyrantel and albendazole twice reduced the prevalence and intensity of A. lumbricoides greater than other groups. However, albendazole-treated children reduced the prevalence and intensity of T. trichiura greater than other groups. This study suggests that two doses yearly of both drugs are more effective than once dose yearly and albendazole treatment once or twice could decrease the intensity of T. trichiura infection.

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Medical Journal of Indonesia,5(4)1996:195-202

Publisher

: ., 1996

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ALBENDAZOLE
pyrantel

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