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A Model for Gene Therapy Utilizing Microencapsulated Recombinant Fibroblants : an In Vivo Study (Model Terapi Gen Menggunakan Sel Fibroblas Rekombinan yang Dibungkus Mikrokapsul : Suatu Kajian In Vivo)

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Current approaches to human gene therapy focus on insertion of a desired gene into autologous cells such as fibroblasta., hepatocytes, bone marrow stem cells of lympocytes. An altemate strategy to gene therapy through genetic modification of the patients own cells is to implant into different recipients the same engineered cell line under immunologically isolated conditions. This in vivo study shows that human growth hormone (hGH) as a novel reporter gene product from microencapsulated genetically modified mouse cells is detectable in the circulation of allogenic recipient mice. On day 3 of post implantation no hGH was detected, 3 ng/ml of hGH was detected on day 12 and increased during the next 9 days up to 10-fold. The high level of hGH was maintained during days 21-33 post implantation and went down afterward to the baseline on day 45. No hGH was detected in the control mouse implanted with the same amount of free recombinant cells.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Berkala Ilmu Kedokteran,28(3)1996:115-120

Penerbit

: ., 1996

Deskripsi Fisik

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Bahasa

ISBN/ISSN

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Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

fibroblasts

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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