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Aktivitas Gastroprotektif Kombinasi Ekstrak Rimpang Kunyit (Curcuma dimestica Linn) dan Kunyit Batang Mimba (Azadirachta indica A. Juss) (Gastroprotective Activity of Combination of Turmeric and Neem Bark Extracts)
Some studies reported that neem (Azadirachta indica A. Juss) bark and turmeric (Curucuma domestica Linn) rhizome extracts demonstrated strong gastroportective activities on various experimental gastriculcer models as well as clinical studies. In this studies, the effect combination of neem bark and turmeric rhizome extracts were studied on ethanol-induced gastric ulcer in rats. That combination was expected to give synergism effect. The combination extracts were administered orally in variousdoses prior ulcer induction. After ethanol administration ulcer index and total acidity were determined. Histopatological examination substantiated the protective effect of the extracts. The combination of neem bark extract (250 mg/kg bw) and turmeric extract (50 mg/kg bw) was observed significantly reduced the ulcer inex. This result also supported by histopatological examinations.
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