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Karakterisasi Kompleks Inklusi Asam Mefenamat- beta-Silodekstrin yang Dibuat dengan Metode Freeze Drying

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Characterization of mefenamic acid- ß-cyclodextrin inclusion compexes by freeze drying method had been studied state mefenamic acid – ß-cyclodextrin inclusion complex orepared by freeze drying method in 1; 1 molar ratio. Mefenamic acid, ß-cycloexrin, mefenaic acid – ß- cyclodexrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (FXRD), Fourier Transform Infrared Spectroscopy (FTIR), Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and ß-cyclodextrin. In vitro dissolution rate studied of mefenamic acid – ß-cyclodextrin physical mixture and inclusion complex were conducted using basked method and water as dissolution medium Mefenamic acid – ß-cyclodexrin inclusion complex showed increasing dissolution rate compared to mafenamic acid-ß-cyclodextrin physical mixture and mefenamic acid.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Kefarmasian Indonesia,1(!): 1-9

Penerbit

Jakarta : Puslitbang Biomedis dan Farmasi., 2009

Deskripsi Fisik

9p.

Bahasa

ISBN/ISSN

2085-675X

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

MEFENAMIC ACID
BETA-CYCLODEXTRINS
FREEZE DRYING

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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