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Karakterisasi Kompleks Inklusi Asam Mefenamat- beta-Silodekstrin yang Dibuat dengan Metode Freeze Drying

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Characterization of mefenamic acid- ß-cyclodextrin inclusion compexes by freeze drying method had been studied state mefenamic acid – ß-cyclodextrin inclusion complex orepared by freeze drying method in 1; 1 molar ratio. Mefenamic acid, ß-cycloexrin, mefenaic acid – ß- cyclodexrin physical mixture and inclusion complexes were characterized by Powder X-ray Diffraction (FXRD), Fourier Transform Infrared Spectroscopy (FTIR), Differential Thermal Analyzer (DTA) and dissolution studies. The results showed the formation of inclusion complex between mefenamic acid and ß-cyclodextrin. In vitro dissolution rate studied of mefenamic acid – ß-cyclodextrin physical mixture and inclusion complex were conducted using basked method and water as dissolution medium Mefenamic acid – ß-cyclodexrin inclusion complex showed increasing dissolution rate compared to mafenamic acid-ß-cyclodextrin physical mixture and mefenamic acid.

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Series Title

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Call Number

Jurnal Kefarmasian Indonesia,1(!): 1-9

Publisher

Jakarta : Puslitbang Biomedis dan Farmasi., 2009

Collation

9p.

Language

ISBN/ISSN

2085-675X

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

MEFENAMIC ACID
BETA-CYCLODEXTRINS
FREEZE DRYING

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