Pengaruh Pemberian Vitamin C terhadap Aktivitas enzim Delta Aminolevulinic Acid Dehydratase. (&-ALAD), Kadar Hemoglobin dan Basophilic Stippling pada Mencit yang Dipapar Plumbum. | Perpustakaan dan Galeri Kebijakan Kesehatan

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Pengaruh Pemberian Vitamin C terhadap Aktivitas enzim Delta Aminolevulinic Acid Dehydratase. (&-ALAD), Kadar Hemoglobin dan Basophilic Stippling pada Mencit yang Dipapar Plumbum.

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Lead in the blood at high concentration can cause health problem such as binding the SH group in globin molecules which disrupts Hemoglobin synthesis, The conversion of § Aminoleuvilinic acid (§ ALAD) to phorphobilinogen is disrupted as well as in disrupted as well as the in corporation of Fe into phorphirin IX to form the Hemoglobin. Antioxidant teraphy is used to treat poisoning because lead causes free radical production. An antioxidant that can be given is vitamin C breaks down the free radical molecule a non-radical from or to a more stable radical. The present was carnet out to find out the of adsministration effect oral vitamin C for a week, an the activity of § Amino leuvelenic acid dehydratase, the hemoglobin concentration and total basophilic stippling observed in the experimental mice. This research was conducted with randomized groups of male mice (Mus musculus L). The mice were divided into 5 groups of 7 mice each. The hemoglobin concentration was determined using the cynmethemoglobin method. Te activity of the § ALAD was measured according to the method of Wigfield and Farant. The basophilic stippling was counted on blood smear dyed with Giemsa. The data was analysed with Anova then Kruskal Walis and Mann-Whitney tests. The results of the Anova test showed that lead decreased the §ALAD activity in the treatment group (p=0,010). Howeved, in the group which was given lead + vitamin C at a dose of 1000 mg/kg Vitamin C (p=0,001). The conclusions of this study are vitamin C 1000mg/kg for seven days increased the § Aminoleuvelenic acid dehydratase acid dehydratase activity and decreases the basophilic stippling in the experimental animals.

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Belum memasukkan lokasi Pannmed; 4(1):14-20

A000002492

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Judul Seri: -
No. Panggil: Pannmed; 4(1):14-20
Penerbit: Medan : Politeknik Depkes Medan., 2009
Deskripsi Fisik: 7p.
Bahasa
ISBN/ISSN: 1907-3046
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: ASORBIC ACID
HEMOGLOBULINS
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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