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Prospect of Nucleic-Acid Based Immune System-RNAi as Potent Antiviral Agents

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The invention of RNA interference (RNAi) machinery as a gene expression silencer may revoulutionize the approach to infectious diseases treatment. A long-standing problem such as viral resistance to chemotherapeutic agents due to the high rate of mutation seen in HIV-1 may soon be overcome by the application of RNAi as a nucleic-acid based immune system. The RNAi uses dsRNAs converted into multiple siRNAs which is designed to be highly complement to the target RNA (i.e. viral RNAs or mRNAs). Through the incorporation to RISC and unwinding of siRANAs, it target and bind the viral RNAs or mR-NAs of interest, and subsequently destroy it before the viral RNAs are integrated into host genome or mRNAs are translated to become amino acids and later, the viral products. This article and later, the viral products. This article discuss future therapeutic potential of RNAi in response to viral infections.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Cermin Dunia Kedokteran,36((5):340-343

Penerbit

Jakarta : Kalbe Farma., 2009

Deskripsi Fisik

4p.

Bahasa

English

ISBN/ISSN

0125-913X

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

IMMUNE SYSTEM
ANTIVIRAL AGEUTS
RNA NDUCED SITENCING COMPLEX

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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