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Prospect of Nucleic-Acid Based Immune System-RNAi as Potent Antiviral Agents

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The invention of RNA interference (RNAi) machinery as a gene expression silencer may revoulutionize the approach to infectious diseases treatment. A long-standing problem such as viral resistance to chemotherapeutic agents due to the high rate of mutation seen in HIV-1 may soon be overcome by the application of RNAi as a nucleic-acid based immune system. The RNAi uses dsRNAs converted into multiple siRNAs which is designed to be highly complement to the target RNA (i.e. viral RNAs or mRNAs). Through the incorporation to RISC and unwinding of siRANAs, it target and bind the viral RNAs or mR-NAs of interest, and subsequently destroy it before the viral RNAs are integrated into host genome or mRNAs are translated to become amino acids and later, the viral products. This article and later, the viral products. This article discuss future therapeutic potential of RNAi in response to viral infections.

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Detail Information

Series Title

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Call Number

Cermin Dunia Kedokteran,36((5):340-343

Publisher

Jakarta : Kalbe Farma., 2009

Collation

4p.

Language

English

ISBN/ISSN

0125-913X

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

IMMUNE SYSTEM
ANTIVIRAL AGEUTS
RNA NDUCED SITENCING COMPLEX

Specific Detail Info

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Statement of Responsibility

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