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Susceptibility Patterns of Salmonella Typhi and Salmonella Parattyphi A to Ciprofloxacin, Levofloxacin, Chloramphenicol, Tetracycline, Ceftriaxone and Triethoprim-Sulfamethoxazole in Jakarta, 2002-2008

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Enteric fever cause by salmonella enteric subsp. Enteric serovar Typhi (S.typhi) and Salmonella enterica subsp. enterica serovar Paratyphi A (S. paratyphi A), still remain a global problem especially in countries with poor hygiene. The prevalence of typhoid Fever in Indonesia was 358-810/100,000 populqation in 2007, 64% was found in age 3-19 years. Mortality rate varies from 3.1-10.4% among hospitalized patients. Worldwide emergence of multi-drug resistant strains of S. typhi to antimicrobials Chloramphenicol. Trimethoprim-Sulfamethoxazole and Ampicillin has been reported S. typhi strains resistant to fluoroquinolone has also been found in India, United States, United States, United Kingdom, Vietnam, Korea and Many more. This study described susceptibility paterns of S, typhi and S. paratyphi A to several antibiotics in the last six years in Jakarta. S. typhi isolated from blood specimens in Laboratory of Clinical Microbioogy, Faculty of Medicine Univ. Indonesia during 2002-2008were tested for their susceptibility patterns to antibiotics: Ciprofloxaci, Levofloxacin, Chloramphenicol, Cefriaxone, Tetracycline and Trimethoprim-Sulfamethoxazole. Among 35 isolates of S. typhi, all were found susceptible to Ciprofloxacin, Levofloxacin , Tetracycline and Trimethoprim-sulfamethoxazole, and more than 90% were also susceptible to Cloramphenicol and Ceftriaxone. While 6 isolates of S. paratyphi A showed 100% sensitivity to those antibiotics tested. The results showed good susceptibility of all antibiotics agains S. typhi and S. paratyphi A in vitro Novertheless, clinicians must pay attention in the interpretation of this susceptibility patterns due to low number of isolates tested.

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Series Title

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Call Number

Cermin Dunia Kedokteran,36((5):328

Publisher

Jakarta : Kalbe Farma., 2009

Collation

1p.

Language

English

ISBN/ISSN

0125-913X

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Edition

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Subject(s)

ciprofloxacin
ofloxacin
chloramphenicol
SALMONELLA TYPHY
SALMONELLA PARATYPHI A
TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION

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