Uji utagenisitas Benzo (alpa) Piren dengan Metode Mikronukleus pada Sumsum Tulang Mencit Albino (Mus musculus) | Perpustakaan dan Galeri Kebijakan Kesehatan

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Uji utagenisitas Benzo (alpa) Piren dengan Metode Mikronukleus pada Sumsum Tulang Mencit Albino (Mus musculus)

Yana Sumpena - Nama Orang; Rochhestari Sofyan - Nama Orang; Rusi Rusilawati - Nama Orang;

Benzo (α) pyrene (BP) is a carcinogenic compound that is supposed to be able to indusce chromosomal damage. The mutagenic effect of BP has been studied using MN test on poly chromatic erythrocyte (PCE) cells of albino mice femur bone marrow. Mice were injected with 0.1 ml of 03% (b/v) BP subcutaneously at the sholder, every day at the same time for ten days. After 120 days, treated and non treated mice were killed by cervical dislocation. The femur bone marrow cells were examined microscopically by the magnificfication of 2000. The amount of MN in PCE (MNPCE) were evaluated in 1000 PCE cells and called MNPCE frequency. BP treated could increase MNPCE frequency. BP treatment could increase MNPC frequency up to 38.82±8.70 (n=10) per 1000 PCE cells compared to MNPCE frequency of 2.19±0.99 per 1000 PCE cells in control group frequency indicated the relatively high mutagenic effect of BP.

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Belum memasukkan lokasi Cermin Dunia Kedokteran,36(1):23-36

A00002404

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Informasi Detail

Judul Seri: -
No. Panggil: Cermin Dunia Kedokteran,36(1):23-36
Penerbit: Jakarta : Kalbe Farma., 2009
Deskripsi Fisik: 4p.
Bahasa
ISBN/ISSN: 0125-913X
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: CARCINOGENS, ENVIRONMENTAL
BENZO(a) PYRENE
MICRONUCLEUS TESTS
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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