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Kajian terhadap Prospe Pengembangan Bahan Bioaktif buah Mahkota Dewa (p. macrocarpa.) sebagai Kandidat New Chemical Entity (NCE) untuk Pengobatan Kanker (Sitostatika)

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In the last few years there are tendency for cancer study to develop in discovery of new chemical entity (NCE) for new drugs. The needed of NCE based on reality that cancer can be used at one therapy and be implemented as a solution to inhibit a resistant level and very useful in recovery time. Natural products are the most important sources of INCE and could be used from plants. Animals or minerals. Most of the natural products used in Indonesia are recognized from plants. Plants secondary metabolites show promise for cancer chemoprevention, which has been defined as the use of non cytotoxic nutrient or pharmacological agents to enhance intrinsic physiological mechanism that protect the organism against mutant clones of malignant cells. The study of plants secondary metabolites is nowadays moved from improvement of the empiric activity to meet the relationship between the structures of cjemical compounds to its pharmacology activities. Development of study on plants in Indonesia is also pointed on disocovery of NCE for new drugs of cancer and the cellular cytotoxic mechanism of the biological activity. Extracts from the fruit of P. macrocarpa is one of the sources for NCE of cancer drug in Indonesia. Some isolates already isolated from the extracts, i.e. lignin compound C19H20O6. 5-[4(4-Methoxy-phenyl)-tetrahydrofuro [3,4-c]furan-1-yl]-benzene-1,2,3-triol chemotaxonomy Dahlgren and Conqruist system approached indicate that these compounds have anti proliferation and pro apoptotic as their cytotoxic activities. The pharmacology activities from the fruit extracts also have been studied. For cytotoxic activities, the fruit extracts showed IC50 values from 5 to 7.71.µg/ml for leukemia L1210 cell line; and IC50 values 196.74µg/ml for HeLa cell line. The extracts also showed antioxidant activity with IC50 values 103.75 g/ml (most active level). Antihistamine activity showed 6.25; 12.5; 25; 50 and 100%b/v doses could decrease the histamine control significantly (p≤0.05). The review article is needed to support a development and improvement of the fruit extracts of P. macrocarpa to be considered as the most important sources of NCE for new cancer drug.

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Detail Information

Series Title

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Call Number

Buletin Penelitian Kesehatan, 37(1): 23-32

Publisher

Jakarta : Badan Litbang Kesehatan Depkes R.I.., 2009

Collation

10p.

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ISBN/ISSN

0125-9695

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Edition

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Subject(s)

plants, medicinal
CYTOTOXINS

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