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The Effect of Topically Extravirgin Olive Oil On the UVB-Induced Immunosuppression

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UVB radiation may act as immunosuppressive agent through angerhans cels (LCS) depletion correlated with cyclobuthane pyrimidine dimer (CPD), as the most mutagenic photoproducts. Other studies showed that olive oil can prevent various human cancers which are defect of immune-surveillance. The effect of olive in the UVB-induced LCs depletion is still unclear. To discover the topical effect of extravirgin-olive-oil in the LCs depletion. A simple experimental study was performed on foreskins collected from 8 circumicised boys. Each of them was cut in to 3 pieces of 0.5 cm², grouped randomly to: (Olive oil+UVB) group, (placebo+UVB) group, and unirradiated group. They were cultured in DMEN for 24 hours, irradiated with 100mJs0cm² UVB, and olive oil or placebo were ten applied immediately after irradiation. All specimens were fixed in buffered-formalin, paraffin blocked, and cut to be 2 slides, and each of them was stained with anti CD1a or anti-CPD antibody. The pixels of AEC signals were digitally counted based on Photoshop’s selected color histogram. The pixel means of various groups were analyzed by Kruskal-Wallis test and post hoc analysis by Whitney test. Olive oil treated groups showed a very significant (p

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Detail Information

Series Title

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Call Number

Berkala Ilmu Kedokteran, 41(3): 122-126

Publisher

Yogyakarta : FK. Universitas Gadjah Mada., 2009

Collation

5p.

Language

English

ISBN/ISSN

0126-1312

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

plant oils
IMMUNOSUPPRESSION
ULTRAVIOLET RAUS

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