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Serum Iron Level shortly After Iron Supplementation Shortly After and 2 Hours After Meal in Women With Iron Deficiency Anemia

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ncidence of anemia in women in developing countries is still high, that is, around 43%. This incidence rate is far more higher that that I industrial countries , which is ranged between 10-12%. The prevalence of iron deficiency anemia is still high, particularly in developing countries. The cause of the high prevalence of iron deficiency anemia is not known, since it involves various factors. Two of the probable etiologic factors is variability in dosage administration in women with anemia and pharmacokinetic of iron coadministered with food in healthy women have been done, but study on repeated dose has never been conducted. To under stand serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in women with iron deficiency anemia. The research design was a fase II clinical trial. Subject were 24 women with iron deficiency anemia, classified into two groups, who were treated as follows: the first group was consisted of 12 women with iron deficiency anemia, treated with twice-a-day ferrous sulphate tablet @ 300 mg orally, given 2 hours after meal for 12 weeks, Blood samples were taken in week 2,4,6,8,10, and 12 after treatment. Serum (ferric) iron level was measured with Vitros Fe Slides method. Minimum, maximum, and average steady-state iron levels (Css min, Cass max, Css average) of treatmen 1 were 108.78 ± 13.79 ug/dL, 121, 44 ± 15.79 ug/dL, and 115.11 ± 13.13 ug/dL (mean ± SEM), respectively; while minimum, maximum, and average steady-state iron levels (Css min, Css max, Css average) of treatment 2 were 115.5 ± 46.27 ug/dL, 141.36 ± 61.36 ug/dL, and 124.92 ug/dL, and 124.92 ±53.43 ug/dL (mean ± SEM)., respectively. No statistical significant difference were found within treatment in minum steady-state levl between week 2,4,6,8,10,12 after treatment. There was also no significant difference in minimum steady-state level between treatment group in week 2,4,6,8,10 and12. There were no differences in serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in women with iron deficiency anemia.

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Detail Information

Series Title

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Call Number

Berkala Ilmu Kedokteran, 41(3): 111-117

Publisher

Yogyakarta : FK. Universitas Gadjah Mada., 2009

Collation

7p.

Language

English

ISBN/ISSN

0126-1312

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Carrier Type

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Edition

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Subject(s)

iron
ANEMIA, IRON-DEFICIENCY
SERUM

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