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Comparison of Daily vs. Weekly Single-dose Ferrous Sulphate Treatment in Female Junior High School Students With Iron Deficiency Anemia

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Complication of daily treatment of iron efficiency anemia in children is still low. The complicance will be increased if the iron supplementation is given weekly. Previous study showed that there was no significant difference in the increase in hemoglobin level between daily and weekly treatment in prepubertial children. To study the difference in the increase in hemoglobin and serum ferritin levels between daily and weekly single-dose treatment of ferrous sulphate in female junior high school students with iron efficiency anemia after menarche. This was a quasi-experimental study recruiting 179 and 174 anemic female students in the weekly and daily group, respectively. They receive weekly or daily single-dose of ferrous sulphate capsules. Hemoglobin levels were measured before and after the 12 weeks reatment, while serum ferritin levels were measured before and after in a subset of the study subjects. Mean ±SD levels of hemoglocin before and after iron suppleentaion were 11.18 ±0.51 and 12.79±0.63 g/dl (p+0.001) in the weekly group, and 11.17±0.61 and 12.68±0.57 g/dl (p=0.001) in the daily group. Mean±SD levels of ferritin before and after iron supplementation were 6.95±1.85 and 41.5±33.93 ng.ml (p=0.001) in the weekly group, and 6.61±2.17 and 40.7±22.73 ng/ml (p=0.001) in the daily group. The prevalence of anemia after supplementation is similar in both groups, i.e. 6.7% in the weekly group and 8.0% in the daily group (p=0.63). There were no significance difference in the occurrence of side effects of diarrhea and nausea in both groups (p>0.05). This study concluded that daily vs. weekly ferrous sulphate supplementation did not result in significantly different level of both hemoglobin and serum ferritin after treatment. The difference in the occurrence of side effects was also not statistically significant.

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Detail Information

Series Title

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Call Number

Berkala Ilmu Kedokteran, 41(1):26-32

Publisher

Yogyakarta : FK. Universitas Dadjah Mada., 2009

Collation

7p.

Language

English

ISBN/ISSN

0126-1312

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ANEMIA, IRON-DEFICIENCY
FERROUS COMPOUNDS
FERRITINS

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